Differences

This shows you the differences between two versions of the page.

--- en:dosis [2023/11/30 21:09] – christian_klopfenstein
+++ en:dosis [2023/11/30 21:43] (current) – christian_klopfenstein
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-===== Dose or Unit Dose (different scenarios) =====
+===== Dose or Unit Dose (different frameworks) =====
-The concept of a "Unit dose of a drug" is used in different scenarios related to drug use.
+The concept of a "Unit dose of a drug" is used in different referential frameworks related to drug use.
 ====Instructions for treatment of a human or animal ====
-In this scenario, the "unit dose" is defined  as the amount of medication given at a specific time (most common definition found on the web).  For example, 250 mg in the morning, 10 mL (2 drops) in the morning, 1 pill after lunch, etc.
+In this referential framework, the "unit dose" is defined  as the amount of medication given at a specific time (most common definition found on the web).  For example, 250 mg in the morning, 10 mL (2 drops) in the morning, 1 pill after lunch, etc.
 ==== Instructions for preparing a dosage regimen (mg/kg/day) ====
-In this scenario, the unit dose is defined as the amount of medication given weight units (kilogram or pounds) per day.  For example, 20 mg/kg*day.  This is the standard working procedure to describe and compare drug doses in food animal veterinary medicine.  The proposed dose, available on a body weight basis, is used by the health professional to prepare a dosage regimen to medicate the animal patient.
+In this referential framework, the unit dose is defined as the amount of medication given weight units (kilogram or pounds) per day.  For example, 20 mg/kg*day.  This is the standard working procedure to describe and compare drug doses in food animal veterinary medicine.  The proposed dose, available on a body weight basis, is used by the health professional to prepare a dosage regimen to medicate the animal patient.
 ==== Instructions for preparing medicated foods (mg/kg of food) ====
-In this scenario, the unit dose is defined as the amount of medication added per weight unit of food to be distributed  to a patient (ex: 600 mg/kg of feed, 600 g/tonne or 600 PPM).
+In this referential framework, the unit dose is defined as the amount of medication added per weight unit of food to be distributed  to a patient (ex: 600 mg/kg of feed, 600 g/tonne or 600 PPM).
 ==== Instructions for preparing medicated water (mg/liter of water)   ====
-In this scenario, the unit dose is defined as the amount of medication added per volume of water (liter or gallon) to be distributed to a patient.
+In this referential framework, the unit dose is defined as the amount of medication added per volume of water (liter or gallon) to be distributed to a patient.
 ==== Defined Daily Dose (DDD) is a statistical measure of drug use in humans (mg/day)  ====
-DDD is a statistical measure of drug consumption developed by the World Health Organization (WHO) used to standardize the comparative usage of various drugs between themselves or between different healthcare environments independently of cost or drug and formulation. In this scenario, the "unit dose" is defined as the amount of medication given to a 70 kg adult human on a daily basis.  The unit of a DDD measure differs from the unit of the DDDvet measure (mg/day versus mg/kg/day, respectively).
+DDD is a statistical measure of drug consumption developed by the World Health Organization (WHO) used to standardize the comparative usage of various drugs between themselves or between different healthcare environments independently of cost or drug and formulation. In this referential framework, the "unit dose" is defined as the amount of medication given to a 70 kg adult human on a daily basis.  The unit of a DDD measure differs from the unit of the DDDvet measure (mg/day versus mg/kg/day, respectively).
 More details in the following website [[https://www.whocc.no/ | (ATC and DDD an international language for drug utilization research) ]]
 ====Defined Daily Dose (DDDvet) is a statistical measure of drug use in animals (mg/kg/day)  ====
-DDDvet is a statistical measure of drug consumption developed by the European countries and Canada to standardize the comparative usage of drugs (mainly antibiotics). In this scenario, the unit dose is defined as the amount of medication given to one kg of an animal on a daily basis.  The unit of a DDDvet measure differs from the unit of the DDD measure (mg/kg/day  versus mg/day, respectively).
+DDDvet is a statistical measure of drug consumption developed by the European countries and Canada to standardize the comparative usage of drugs (mainly antibiotics). In this referential framework, the unit dose is defined as the amount of medication given to one kg of an animal on a daily basis.  The unit of a DDDvet measure differs from the unit of the DDD measure (mg/kg/day  versus mg/day, respectively).
 More details in the following document :
 [[https://www.ema.europa.eu/en/documents/other/defined-daily-doses-animals-dddvet-defined-course-doses-animals-dcdvet-european-surveillance_en.pdf |ESVAC 2016 « Defined daily doses for animals DDDvet) and defined course doses for animals (DCDvet) »]].